We found that hNVs, hNVs-EGCG and hNVs@Flu-EGCG groups had a high proportion of M1 macrophages (CD80+) than PBS and PLGA-Flu groups, and M2 macrophages (CD206+) were lower in hNVs, hNVs-EGCG and hNVs@Flu-EGCG groups than those in PBS and PLGA-Flu groups, which indicated the enhanced tumor-suppressing effects (Fig. 6A). The gene discussed is CD80; the disease is neoplasm.