Subsequently, the ELISA results of the tumor tissue demonstrated that the higher levels of TNF-α and IL-6 in hNVs, hNVs-EGCG and hNVs@Flu-EGCG groups and lower levels of IL-10 in hNVs, hNVs-EGCG and hNVs@Flu-EGCG groups compared to PBS and PLGA-Flu groups, showed the same result as before (Fig. 6B). The gene discussed is TNF; the disease is neoplasm.