The gained/amplified cytobands comprised 725 genes including 8 defined as driver alterations by CGI: HER2, CCND1, MYC, EGFR, PIK3CA, FGFR2, MDM4, and AKT3, as well as FGFR1, ZNF703. The two most significant gained/amplified cytobands (17q12 and 11q13.3) were regions classically amplified in breast cancer. The gene discussed is MDM4; the disease is breast carcinoma.