TNF and alopecia areata: In addition to this, MJ04 was seen to dampen the level of proinflammatory cytokines, i.e., TNF-α, IL1-β, and IL-6 in the LPS primed macrophages, thereby reiterating its role in effectively inhibiting polarization of naïve T-cells into the proinflammatory immunophenotypes in order to reinstate the immune homeostasis and manage the autoimmune inflammatory response associated with induction of alopecia areata [49, 50].