As shown in Fig. 5, the surface of the template was magnetized with gold-coated magnetic nano-stars (Au-MNS) modified with a SERS-tag consisting of specific antibodies for three sepsis biomarkers (soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM1)), C-reactive protein (CRP), and procalcitonin (PCT) and a RAMAN dye for RAMAN signal amplification. The gene discussed is TREM1; the disease is Sepsis.