APC and central nervous system cancer: While our study did not explore the overall impact of PRMT6 on m6A modifications in glioma cells, we found that PRMT6 affects the m6A modification of APC and GSK3β mRNA, as overexpression of PRMT6 reduces the m6A levels on these mRNAs (Fig. 7H, Supplementary Material 5: Fig. S5F).