In previous studies, Wang et al. [53] and Li et al. [52] demonstrated in esophageal squamous cell carcinoma and colorectal cancer, respectively, that YTHDF2 binds to m6A -modified APC and GSK3β mRNA, promoting their degradation and activating the Wnt-β-Catenin pathway. This evidence concerns the gene YTHDF2 and esophageal squamous cell carcinoma.