YTHDF2 and glioblastoma: This investigation elucidates the activation of the Wnt-β-Catenin pathway by PRMT6 through transcriptional upregulation of YTDHF2, highlighting the significance of the PRMT6-YTHDF2-Wnt-β-Catenin axis in facilitating GBM’s migration, invasion, and EMT in both in vitro and in vivo contexts.