INS and Hypoglycemia: For instance, the combination of two anticoagulants, ASA and heparin; verapamil (a calcium channel blocker) and midazolam (benzodiazepine); lidocaine (a local anesthetic) with metoprolol and carvedilol (a beta-blocking agent); and anti-diabetic drugs, such as insulin lispro and insulin glargine, with ASA and metoprolol, a beta1 receptor blocker used to treat high blood pressure that can increase the risk of hypoglycemia.