The enrichment analysis revealed an increased presence of hub genes associated with adenoma/adenocarcinoma, malignancy, metastasis, extracellular structure organization, PI3K-Akt signaling pathway, IL-4/IL-13/IL-17 /IL-18, inflammation and inflammatory response pathway, matrix matalloproteinase, and AGE-RAGE signaling pathway (Fig. 2C). This evidence concerns the gene IL4 and adenoma.