P2RY2 and medical procedure: Our laboratory recently used tamoxifen-inducible, endothelial-specific purinergic P2Y2 receptor (P2Y2R), Panx1, and TRPV4 knockout mice in combination with in vivo, ex vivo, and in vitro models of IR to show that lung IR induces endothelial Panx1 channel-mediated efflux of ATP, which then activates endothelial P2Y2R signaling.