Among the 75 patients with Cushing syndrome, information on preoperative serum glucocorticoid and ACTH levels were available for 70, and ACTH levels were slightly lower in the non-fever group than in the fever group (4.5 pg/mL [range, 1.0–19.0] vs. 7.0 pg/mL [range, 2.7–55.0], p = 0.050). Here, POMC is linked to Cushing syndrome.