ALG1 and autosomal recessive disease: Among the six cases of FGR occurring on chromosome 16 reported by Xie et al., three cases expressed CDT1 and two cases expressed ALG1. The database showed that the genes CDT1 and ALG1 were located at 16q24.3 and 16p13.3 and were associated with autosomal-recessive diseases associated with FGR [22].