Chemicals such as Dextran Sodium Sulfate (DSS), Trinitrobenzene Sulfonic Acid (TNBS), and Dinitrobenzene Sulfonic Acid (DNBS) can be used to induce colitis, as well as spontaneous mutations, adoptive T-cell transfer, microbiome induction, and genetic engineering methods like IL-10 knockout mice [8, 11–14]. Here, IL10 is linked to colitis.