In mouse and cell models, TRPA1 activation increases allergic cytokine production such as TSLP and IL-1323,24, worsens barrier function through impact on tight junctions25, can be activated by the types of temperature fluctuations known to worsen AD outcomes5,26, modulates AhR27, is induced by dust mite exposure28, and is upregulated on the skin after consumption of a Western diet29,30. Here, TRPA1 is linked to Alzheimer disease.