Examining transcripts that were downregulated upon IOX5 treatment (and upregulated upon loss of Hif-α) revealed a number of genes known to be overexpressed or to have oncogenic roles in leukemia, including Hspa8, Nup98, Kpnb1 and Rbm15 (refs. 50–53) (Extended Data Fig. 7c). This evidence concerns the gene NUP98 and leukemia.