KPNB1 and leukemia: Examining transcripts that were downregulated upon IOX5 treatment (and upregulated upon loss of Hif-α) revealed a number of genes known to be overexpressed or to have oncogenic roles in leukemia, including Hspa8, Nup98, Kpnb1 and Rbm15 (refs. 50–53) (Extended Data Fig. 7c).