CD4 and ocular melanoma: GEMCOVAC-OM showed significantly higher Omicron B.1.1.529-reactive TNF+CD4+ (P < 0.001), IL-2+CD4+ (P < 0.0001) and IL-2+CD8+ (P < 0.0001) T cells compared with ChAdOx1 nCoV-19 (Fig. 3a–f).