In addition, TL and surface expression of CD160, an important biomarker for cytokine production in NK cells and early control of tumor growth (Tu et al, 2015) was found to be reduced in anergic cells along with the TL and surface expression of DNAM-1 (Du et al, 2018) and 2B4 (Meazza et al, 2017), which are vital receptors responsible for NK cell responses (Fuchs and Colonna, 2006; Enqvist et al, 2015) (Fig. 2B). Here, CD226 is linked to neoplasm.