Collectively, our data highlight the overlap of key significant genes such as DGKA (NK and T-cell viral infection), EGR2 (T-cell viral infection and CD8 T-cell exhaustion), and the potential role of key TFs including EGR2, NFAT2 (NFATc1), and TOX2 in driving NK cell anergy. The gene discussed is EGR2; the disease is viral infectious disease.