The HLA class I alleles HLA-A*02:01 and HLA-B*40:01, related to high COVID-19 vaccine response, were found, as well as HLA-A*03:01, HLA-B*08:01 HLA-B*18:01, and HLA-C*07:01 related to low vaccine response. The gene discussed is HLA-B; the disease is COVID-19.