Besides, the transcriptome of peripheral blood immune cells was also used to evaluate the impact of prior BNT162b2 vaccination on the innate immune response of hospitalized COVID-19 patients infected with the SARS-CoV-2 Beta variant, revealing an enhanced JAK-STAT-mediated immune response at day 10 in vaccinated individuals, in comparison to unvaccinated ones75. This evidence concerns the gene SOAT1 and COVID-19.