PTPRC and autoimmune lymphoproliferative syndrome: Such hematopoietic alterations were not due to the development of autoimmune lymphoproliferative syndrome (ALPS)-like disease because none of the mice displayed autoimmune-related features at the time of analysis, as shown by negativity for autoimmune antibodies (anti-nuclear antibody and anti-dsDNA) (Fig. S8b) and normal levels of immunoglobin (Fig. S8c), as well as negativity for CD4−CD8−CD3+B220+ double-negative T-cells (Fig. S8d).