RB1 and cancer: These statins have been linked to an increase in chromosomal abnormalities in RB-deficient tumor cells, hinting at their potential application for the treatment of RB-deficient tumors.134 Ongoing clinical trials are currently examining the efficacy of simvastatin against various cancers, including breast (NCT00807950, NCT05550415), gastric (NCT01099085, NCT03086291), colorectal (NCT01238094), and bladder (NCT02360618) cancer.