This capacity to modulate PD‐L1 has been further confirmed in co-culture settings with Jurkat T cells, where apigenin was shown to not only increase T lymphocyte proliferation, but also promote their apoptosis in breast cancer (MDA‐MB‐468) and melanoma (A375) cells.259,260 These findings highlight the intertwined relationship between T cell activation, apigenin-dependent PD-L1 regulation, and subsequent cancer cell demise. This evidence concerns the gene CD274 and cancer.