PIK3CA and cancer: The rapid proliferation of cancer cells is sustained through corresponding adaptations in tumor metabolism, which involve the activation or modification of metabolic pathways to harness more energy.97 Deregulating cellular energetics has recently been added as a new hallmark of cancer.98 Current research on metabolic reprogramming has primarily focused on the aberrant activation of the PI3K/AKT/mTOR pathway, as well as activation of oncoproteins such as MYC, RAS, pyruvate kinase M2 (PKM2), and hypoxia-inducible factor 1 (HIF-1).