PTGS2 and cancer: Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is conventionally prescribed for adult arthritis.178 However, recent studies have described the anticancer properties of celecoxib, which are mediated through the suppression of COX-2, a factor that is closely associated with cancer-related inflammation by promoting the synthesis of various prostaglandins, such as prostaglandin E2 (PGE2).