STAT3 and neoplasm: For example, Yang et al. found that EVO impeded the growth of H. pylori reference strains and clinical isolates, as well as reduced the translocation of CagA and VacA proteins into AGS GC cells.341 EVO appears to exert its protective effects against CRC through modulation of the gut microbiota and reduction of intestinal inflammation, potentially through inhibition of the IL6/STAT3/P65 signaling pathway.342 In addition to its direct anticancer effects, EVO has also been shown to temper inflammatory reactions and tumor-associated immune responses.