This collection of variants includes the most common missense variants in AAT in terms of allele frequency (AF) that have been reported in the general population (gnomAD database51) including M1 (V237A; 22% AF), M2 (R125H; 15.6% AF), M3 (E400D; 27% AF), S (E288V; 2.3% AF), Z (E366K; 1.1% AF) and others that have >0.1% AF. The gene discussed is SERPINA1; the disease is atrial fibrillation.