Given the impact of secreted monomer and NE inhibitory activity on lung disease, we plotted the normalized residue positions for all the measured missense variants (Fig. 3a, x axis, full-length polypeptide chain noted “1”) relative to their secreted monomer levels (Fig. 3a, y axis) to understand the impact of GRP94 on NE inhibitory activity for the entire protein sequence (Fig. 3a, z axis, color scale) in the absence (Fig. 3a, left panel) or presence of PU-WS13 (Fig. 3a, right panel). The gene discussed is HSP90B1; the disease is lung disorder.