Western blot and qRT-PCR revealed that DDP downregulated GPX4 and SLC7A11 protein (Fig. 1B) and mRNA (Fig. 1C) levels in NPC cells dose-dependently, whereas Ferrostatin-1 led to a rebound of GPX4 and SLC7A11 (Fig. 1B, C). The gene discussed is GPX4; the disease is nasopharyngeal carcinoma.