Fn can activate the NF-κB pathway, resulting in the upregulation of pro-inflammatory cytokines and chemokines, which leads to the formation of a pro-inflammatory TME and the selective recruitment of bone marrow-derived immune cells, including bone marrow-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), TAMs, and dendritic cells (DCs) [10, 28]. Here, NFKB1 is linked to neoplasm.