Meanwhile, macrophages can promote tumor invasion and metastasis through secretion of various cytokines (e.g., TGF-β, IL-10, arginase 1) and chemokines (e.g., CCL5, CCL17, CCL18, CCL22) [18, 22, 27, 70–73]. The gene discussed is TGFB1; the disease is neoplasm.