In group-R, cluster 1 mainly presented the down-regulation of oxidative phosphorylation and non-alcoholic fatty liver disease pathways, and down-regulated genes expression related to NADH dehydrogenase activity and oxidoreductase activity; and cluster 6 presented the up-regulation of genes expression of ubiquitin conjugating enzyme activity. Here, ENSG00000254051 is linked to alcoholic fatty liver disease.