ALOX15B and eosinophilic esophagitis: ALOX15 encodes a 15-lipoxygenase whose metabolites promote polarization of macrophages to an M2 phenotype34; higher esophageal expression of ALOX15 has been described in refractory or relapsing patients70, whereas downregulation of ALOX15 expression characterizes mild EoE with a normal-appearing esophagus71.