FLG and eosinophilic esophagitis: Epithelial cells, especially apical cells, expressed CAPN5/14, FLG, and SHROOM3. CAPN5/14 and SHROOM3 expression also correlated across apical cells (minimum Spearman ρ = 0.52, Supplementary Fig. 10b), indicating a potential apical cell-specific contribution to EoE pathophysiology.