Esophageal DC subsets included conventional type 1 dendritic cells (cDC1s), cDC2Bs and IL22RA2+CLEC10A− cDC2As recently discovered in the spleen40, and a subset of PRDM16+ cDC2Cs expressing the EoE risk gene ATP10A that were rare in healthy tissue and enriched in active EoE. Here, ATP10A is linked to eosinophilic esophagitis.