Compared to those in healthy participants, TH17 cells were depleted in patients with active EoE in both the public data (FDR < 0.001, Fisher’s exact test; Fig. 4e) and our data (Fig. 2a) and downregulated IL17A/F, IL22, and IL26 (FDR < 0.001, likelihood-ratio test, Fig. 4f). This evidence concerns the gene IL17A and eosinophilic esophagitis.