DSC2 and eosinophilic esophagitis: The epithelial compartment included four subsets: quiescent basal cells expressing TSLP (an EoE risk gene), CXCL14, IL1R2, and KRT14/15; apical cells expressing KRT78 and CRNN; cycling basal cells; and suprabasal cells expressing a mix of basal, apical, and cell type-specific genes, such as SERPINB3/4 and DSC2 (Fig. 1d, Supplementary Data 2).