In particular, fibroblast genes dysregulated in active EoE and normalized fully or partly in remission were highly enriched for positive immune regulators (Fig. 5b), including IL13RA2, IGF2, C3, CFD, IGFBP2, GAS6, and C1S (Fig. 5c). This evidence concerns the gene C1S and eosinophilic esophagitis.