Of the nine causal genes of Mendelian diseases associated with EoE, four (STAT3, PTEN, ERBB2IP, and TGFBR2) were expressed in stromal cells and myeloid cells, two (DOCK8 and TGFBR1) were also frequently expressed in myeloid cells, two (DSP and SPINK5) were mostly expressed in epithelial cells, and one (DSG1) was weakly expressed (Supplementary Fig. 10a, Methods). Here, SPINK5 is linked to eosinophilic esophagitis.