It is also worth recalling that ketoconazole––a widely used agent for Cushing’s syndrome––is itself an aromatic hydrocarbon and, in addition to its action on the first and last step of steroidogenesis, interacts with the AHR complex and activates hepatic AHR-dependent gene transcription [9]. The gene discussed is AHR; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.