Let-7 targets multiple oncogenes (RAS, c-MYC, HMGA2 to date) and the prominent mechanisms by which let-7 exerts a tumor suppressive role is by repressing the translation of the three RAS proteins (HRAS, NRAS, and KRAS) and c-MYC, a downstream effector of RAS-ERK signaling [1, 23–27]. This evidence concerns the gene MYC and neoplasm.