PTGS2 and neoplasm: Similarly, the loss of COX2 did not alter the frequency of tumor-associated macrophages (TAM; Supplementary Fig. S6F) but induced proinflammatory polarization of both CD11b+ and CD11c+ TAMs with increased expression of both CD86 and MHC II (Fig. 2F; Supplementary Fig. S6G) as well as decreased expression of the M2 markers arginase and CD206 (Fig. 2G and H; Supplementary Fig. S6H).