Although some reports have shown that PAR-2 activation results in the phosphorylation of eNOS at Ser1177 in human endothelial cells and rat aorta with metabolic syndrome [30–32], another study reported that PAR-2 suppressed eNOS phosphorylation at Ser1177 in the aorta of diabetic mice [33]. The gene discussed is F2RL1; the disease is metabolic syndrome.