IL6 and endothelial dysfunction: Angiotensin II promotes coronary artery injury possibly through various pathophysiological phenomena, such as modulation of the inflammatory response, stimulation of the production of multiple cytokines, such as IL-6, TNF-α, and COX-2, and promotion of the generation of reactive oxygen species, enhanced oxidative stress, decreased nitric oxide production, and increased endothelial dysfunction [3].