The R298Q/W mutation in ribonucleotide reductase that was detected in three cases of UCEC and one case of GBM was able to produce a missense mutation in the RRM2 gene, thus causing translation from R (arginine) to W (tryptophan) or glutamine (Q) at position 298 of the RRM2 protein. Here, RRM2 is linked to glioblastoma.