For age, significant correlations with RRM2 expression were observed in 0–29 years group (BRCA, KIRP, LUAD, PCPG, READ, STAD, TGCT (Testicular Germ Cell Tumors)), 30–49 years group (ESCA, KIRC, LAML (Acute Myeloid Leukemia), LIHC, THYM (thymoma)), 50–70 years group (LGG (brain lower-grade glioma)), LUSC), and over 70 years group (KICH (Kidney Chromophobe), PAAD (pancreatic adenocarcinoma)) (Fig 2A–2D and S1A-S1L Fig in S1 File). Here, RRM2 is linked to pancreatic adenocarcinoma.