In terms of tumor status, RRM2 expression levels were significantly correlated with COAD and OV (ovarian serous cystadenocarcinoma) in tumor free group, ACC, BLCA, KICH, KIRC, KIRP, LGG, LUAD, PAAD, PCPG, PRAD and UVM (Uveal Melanoma) in tumor group (Fig 2M–2P and S1Y-S1AG Fig in S1 File). This evidence concerns the gene RRM2 and adrenal cortex carcinoma.