As presented in Fig 3A–3E and S2A-S2I Fig in S1 File, OS analysis data revealed high RRM2 expression was associated with poor prognosis for the TCGA cases of ACC (P<0.001), KICH (P = 0.015), KIRC (P<0.001), KIRP (P<0.001), LGG (P<0.001), LIHC (P = 0.005), LUAD (P<0.001), MESO (Mesothelioma) (P<0.001), PAAD (P = 0.006), PRAD (P = 0.004), SARC (Sarcoma) (P = 0.04), UCEC (P = 0.021), and UVM (P<0.001). The gene discussed is RRM2; the disease is adrenal cortex carcinoma.