This is consistent with very high PRL levels (> 100 μg/L) observed in patients with prolactinomas and in rodent models of excessive hyperprolactinemia [46, 58, 59] being deleterious for metabolism [18, 19, 60–63] and with levels within the HomeoFIT-PRL values (< 100 μg/L) being metabolically beneficial. The gene discussed is PRL; the disease is hyperprolactinemia.