Obese mice developed insulin resistance, as shown by a decreased response in reducing glucose levels upon insulin stimulation during the ITT (minutes 15 (p < 0.001), 30 (p < 0.05), 120 (p < 0.05)), while obese mice treated with sulpiride showed improved insulin sensitivity, evidenced by a larger decrease in glucose levels after insulin injection (minutes 15 (p < 0.01), 120 (p < 0.05); AUC (p < 0.001)) (Fig 2B). The gene discussed is INS; the disease is Insulin resistance.