However, unlike the effect observed in VAT, sulpiride did not cause alterations in the expression of Insr, Glut4 and Hif1α, being Prlr and Glut4 the only genes downregulated in obesity, indicating that the effects of sulpiride on SAT may be mediated through different mechanisms. The gene discussed is INSR; the disease is obesity due to melanocortin 4 receptor deficiency.