Chromatin immunoprecipitation assays have confirmed the binding of estrogen receptor B to the SOX4 gene promoter in prostate adenocarcinoma cells (LNCaP), suggesting a regulation of SOX4 through estrogen signaling, a prominent process in controlling the timing of labor onset in the myometrium (reviewed in [7,37]). The gene discussed is SOX4; the disease is prostate adenocarcinoma.