To expand on siRNA targeted inhibition of YAP and TAZ we tested the effects of pharmacologically targeting YAP/TAZ with verteporfin (VP) and CA3, two known YAP/TAZ inhibitors, on VM formation in vitro, using the aggressive Cl.2A human melanoma cells and the two highly cerebrotropic derivatives of mouse melanoma cell lines, YUMM1.1Br and B16.F10 [61–65]. This evidence concerns the gene YAP1 and melanoma.