YAP1 and neoplasm: We found that VM density is higher in MBM compared to extracranial melanoma metastases and that VM density, but not blood vessel density, is associated with tumor volume and edema in MBM. We also establish the utility of anti-YAP/TAZ therapy in mouse models of metastatic melanoma and note that treatment effectively inhibits VM and prolongs survival of mice with MBM, suggesting that targeting VM might be a promising strategy for treating MBM.