While studies to identify target genes of YAP/TAZ that mediate their activity in VM are lacking in melanoma, in other cancers it was found that YAP/TAZ induce VM by regulating the embryonic stem cell transcription factor SOX2 or by upregulating pro-angiogenic factors such as CYR61 and ANG2 [21]. The gene discussed is YAP1; the disease is melanoma.