Among all the antibodies with differences, 12 IgG antibodies against Jo-1, SSB, PL-12, PM/scl100, Scl-70, TIF1γ, β-actin, MPO, TTG, AQP4, calprotectin, and CRP were more abundant in patients with autoimmunity than in those without (p < 0.05). The gene discussed is ACTB; the disease is Autoimmunity.