Finally, the results of GSEA identified that nine pathways were associated with LRRFIP1 in pancreatic cancer, including "pancreatic cancer signaling", "Wnt signaling", Hedgehog signaling pathway", "PI3K/AKT/mTOR_VITD3 signaling", "Integrin signaling pathway, "Integrin-mediated cell adhesion signaling", "RhoA pathway", "Toll-like receptor signaling related to MYD88", and "Interferon alpha/beta signaling". This evidence concerns the gene RHOA and familial pancreatic carcinoma.