Nine pathways, including "Pancreatic cancer", "Signaling by Wnt in cancer", "Hedgehog signaling pathway", "PI3K/AKT/mTOR_VITD3 signaling", "Integrin signaling pathway", "Integrin-mediated cell adhesion signaling", "RhoA pathway", "Toll-like receptor signaling related to MYD88", and "Interferon alpha/beta signalling" were identified enriched in the pancreatic cancer patients with high LRRFIP1 expression (Fig.  5A–I). This evidence concerns the gene LRRFIP1 and familial pancreatic carcinoma.