Nemaline myopathies are associated with pathogenic variants in at least 13 genes: ACTA1, NEB, LMOD3, TPM3, TPM2, TNNT1, TNNT3, CFL2, MYPN (all encoding protein components of the muscle thin filament), KBTBD13, KLHL40, KLHL41 (all likely involved in protein turnover in the muscle sarcomere via the ubiquitin–proteasome pathway), and MYO18B [54, 85]. This evidence concerns the gene ACTA1 and nemaline myopathy.