STAT3 and Autoimmunity: Moreover, of the four genetic etiologies of autoimmunity and autoinflammation (i.e., STAT1 GOF, STAT3 GOF, APDS, and MIS-C) analyzed simultaneously, STAT3 GOF had the largest number of DE genes in common with PD-1 deficiency, suggesting a partial overlap in pathophysiology between these disease conditions (Fig. 7 D and Table S7).