We, thus, performed a coculture assay with EV- or PD-1-transduced HuT78 T-lymphoma cells and EV- or PD-L1-transduced Raji B-lymphoma cells to evaluate the suppressive function of the WT and mutant PD-L1 proteins in the presence of PD-1 (Fig. 3 C) (Ogishi et al., 2021). Here, PDCD1 is linked to lymphoma.