The close interaction between 14‐3‐3 and Tau proteins has been proven to play key roles in AD[20] and PD.[33] 14‐3‐3 can bind to Tau and protein kinase simultaneously, which makes Tau a more suitable substrate for various kinases.[19] Our study found that hsa_circ_0001546 promoted the direct binding between 14‐3‐3, CAMK2D, and Tau and then caused abnormal phosphorylation of the Tau protein at the Ser324 site. The gene discussed is MAPT; the disease is Alzheimer disease.