MAPT and neurodegenerative disease: Abnormal phosphorylated and aggregated Tau protein can cause iron accumulation, oxidative stress, and lipid peroxidation and finally result in ferroptosis to promote memory impairment induced by Alzheimer's disease.[9] Besides, tau protein misfolding was found to be related to iron accumulation in Alzheimer's disease, which caused oxidative stress, neuron loss, and ferroptosis.[10] Although the relationship between Tau and ferroptosis has been illustrated in neurodegenerative diseases, there is still a lack of relevant studies in cancers.