Despite the small sample size of cognitively healthy centenarians, the association for 8 out of 85 SNPs with AD reached significance after correction for multiple testing (false discovery rate [FDR] < 5%): ANKH, GRN, PLCG2, RIN3, ABCA7, BIN1, and the two APOE SNPs, Figure 1 and Table S3). Here, GRN is linked to Alzheimer disease.