The average fluorescence intensity for 6E10‐positive Aβ was higher in the hippocampus of AD patients than HCs (148.65 ± 29.34 vs 38.67 ± 18.24, p < 0.001), while the average fluorescence intensity for mGluR5 and SV2A was lower in the hippocampus of AD patients than HCs (51.86 ± 25.10 vs 116.21 ± 38.21, p = 0.016; 47.73 ± 18.90 vs 86.65 ± 15.16, p = 0.008) (Figure S2). The gene discussed is GRM5; the disease is Alzheimer disease.