Since the C allele of rs1800795 largely determined serum IL‐6 levels8, 17, 18 and thus linked to CAD3, 4, 5 and atherosclerosis,7, 8, 9, 10, 11, 12 an increasing number of C allele will no doubt disturb cardiometabolic and increase the risk of PCAD. The gene discussed is IL6; the disease is atherosclerosis.