CDK4 and neoplasm: Trafficking and localization of T cells is mainly regulated by C‐X‐C motif chemokine receptor 3 (CXCR3)[16] following gradients of C‐X‐C motif chemokine ligand (CXCL) 9,[17] 10,[18] or 11.[19, 20] These chemokines are secreted by tumor cells and non‐malignant cells within the TME, determining the numbers of tumor‐infiltrating T cells.[21] However, the expression of CXCL9, 10, or 11 in most tumors is limited, which has been linked with poor T cells infiltration.[18] Cyclin‐dependent kinase 4 and 6 (CDK4/6) are critical mediators of cellular transition into S phase of the cell cycle.