That is : i) shell encapsulating IDOi was ruptured in response to acidic pH in TME, contributing to 1st release of IDOi, and consequently enhancing the activation of T cells (Figures 3a‐e and 7), and then ii) GSH‐sensitive core loading CDK4/6i was internalized by tumor cells, and achieved a 2nd release of CDK4/6i, leading to an up‐regulated expression of inflammatory chemokines as well as MHC‐I, and thus an increased infiltration and activation of T cells in tumor (Figures 3f,g and 6). Here, CDK4 is linked to neoplasm.