At the same time, the 1st released core was internalized by tumor cells and degraded by intracellular GSH, to realize a 2nd release of CDK4/6i in tumor cells, which induced an up‐regulated expression of CXCL10 and CCL5, and thus a significantly increased tumor infiltration of T cells (Figure 1c). This evidence concerns the gene CXCL10 and neoplasm.