Conversely, downregulation of UBE2C rescued p53 expression and sensitized these two cell lines to TMZ regardless of the status of TP53, indicating that UBE2C enhances TMZ resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma regardless of the mutational status ofTP53 in tumor cells. Here, UBE2C is linked to central nervous system cancer.