LATS1 and neoplasm: Upon phosphorylation by Mst1/2 and Lats1/2, YAP/TAZ dephosphorylates and dissociates from cytoplasmic 14-3-3 kinase to enter the nucleus where it interacts with TEAD and other factors to initiate transcriptional expression of downstream target genes and promote stemness maintenance in tumor CSLCs [13].