In this context, the objectives of the present study were: (1) to explore the association of levels of the BTM (osteocalcin [OC]), beta-CrossLaps [β-CTX] and N‐amino terminal propeptide of type I collagen [P1NP] with BMD in patients with T1D and T2D; (2) to provide information if genetic variants within the VDR gene polymorphisms may predispose to increased osteoporosis in diabetic patients. This evidence concerns the gene VDR and type 1 diabetes mellitus.