Furthermore, a CTNNB1 mutant mouse HCC model induced by Phenobarbital (PB) and Diethylnitrosamine (DEN) demonstrated that inhibiting β-catenin expression with locked nucleic acid (LNA) antisense oligonucleotides resulted in decreased HCC cell proliferation and increased apoptosis. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.