In AMD and AD pathogeneses share several risk factors such as age, obesity, atherosclerosis, and hypertension (Kaarniranta et al., 2011) but share also several mechanisms, such as inflammation, tau hyperphosphorylation, oxidative stress, drusen and alternative complement cascade activation (Meri and Haapasalo, 2020). The gene discussed is MAPT; the disease is obesity due to melanocortin 4 receptor deficiency.