Progressive supranuclear palsy (PSP) shows subcortical tau deposits, corticobasal degeneration (CBD) has asymmetric cortical tau deposits, Huntington’s disease affects the caudate nucleus, AD begins in the hippocampus and spreads, amyotrophic lateral sclerosis targets motor neurons in the spinal cord and motor cortex, and frontotemporal dementia (FTD) affects the prefrontal and orbitofrontal cortex, as well as anterior and medial temporal regions (Chiti and Dobson, 2017; Dugger and Dickson, 2017; Jack et al., 2018). Here, MAPT is linked to juvenile Huntington disease.