Regarding the iron chelator, deferasirox (Figure 3 7th line), previous studies demonstrated that iron overload directly correlated with cognitive decline in AD, and ferroptosis, a type or programmed cell death process characterized by iron overload and triggered by lipid peroxidase, has been shown to be involved in the generation of Ab plaques and tau accumulation in AD (Wang et al., 2022). Here, MAPT is linked to Alzheimer disease.