The results showed that there was significantly different in CSF biomarkers (Aβ42, T-tau, P-tau, Aβ42/T-tau, and Aβ42/P-tau) (P < 0.01), PA (P < 0.05), age (P < 0.01), years of education (P < 0.01), alcohol history (P < 0.05), hypertension (P < 0.01), and diabetes (P < 0.01) between POD and NPOD groups. Here, MAPT is linked to Hypertension.