Furthermore, study investigators from a recent IP‐1 PROSTAGRAM statistical report suggested that the use of a combination of PSA ≥1 ng/mL and MRI score ≥4 thresholds, in the first round of future screening programmes, may facilitate the detection of grade group ≥2 cancers, while reducing biopsy referrals, suggesting multiple viable routes to reducing harms associated with overdiagnosis.38 The gene discussed is IKBKG; the disease is cancer.