Since HIV-DLBCL is often EBV-associated [which has been shown to be linked to low expression of the TGFβ receptor in other B-cell lymphomas (Inman and Allday, 2000)], further investigation as regards the frequency of epigenetic silencing of TGFβ-related genes and the potential value of demethylating agent therapy in the setting of HIV-DLBCL would be of interest. The gene discussed is TGFB1; the disease is B-cell non-Hodgkin lymphoma.